Pirprofen in treatment of non-articular rheumatism in Pakistani outpatients, a multicentre study.

This study was conducted by 50 leading family physicians and consultants scattered throughout Pakistan to evaluate efficacy and tolerability of Pirprofen in non-articular rheumatism in Asian populations. A total of 199 subjects suffering from soft tissue rheumatism completed 2 weeks therapy. Evaluation of patient’s condition was made on days 0, 7 and 14, seven target symptoms and signs were evaluated on four point scale (i.e. absent, mild, moderate or severe). At the end of two weeks of treatment each patient gave his own evaluation of the effectiveness of treatment and physician made his final assessment. Pirprofen was found to be an efficacious drug in treatment of soft tissue rheumatism in Pakistani patients, and its tolerability compared well with other non-steroidal anti-inflammatory drugs. Marked response to treatment was found in each of 7 signs and symptoms studied even after only one week of treatment. This is particularly encouraging as these were precisely the signs and symptoms that would have kept a person from work, or prevented him from performing without restrictions his routine day to day activities. In this study the rapid onset of analgesic effect and improvement of symptoms with low incidence of side effects establishes Pirprofen as a drug of choice for treatment of soft tissue rheumatism (JPMA 38:265 , 1988).